St. Luke’s has been providing compassionate healthcare to Houstonians for over five decades from its flagship hospital location in the Texas Medical Center.  Founded in 1954 by the Episcopal Diocese of Texas, St. Luke’s Episcopal Hospital delivers primary and tertiary healthcare to patients from the local area and from around the world.

Since 1962, St. Luke’s Episcopal Hospital has maintained a valuable relationship with its research and education partner Texas Heart Institute. Together, the two have achieved numerous milestones, including the nation’s first successful human heart transplant.

In 1971, a 26-story patient tower was constructed, and in 1990, St. Luke's Medical Tower (now known as The O'Quinn Medical Tower at St. Luke's) opened, earning the distinction of being the icon most associated with the Texas Medical Center.  In January 2002, The Denton A. Cooley Building was dedicated.

In 1997, St. Luke’s established St. Luke’s Episcopal Health System and created St. Luke’s Episcopal Health Charities, which is now the largest local faith-based charity devoted to health services.

In 2000, the opening of the first St. Luke's Community Emergency Center^® expanded St. Luke's Emergency Services to further support our mission of service to the community.  We have grown to be the largest provider of freestanding emergency services in the greater Houston metropolitan area.  St. Luke's prides itself in bringing Texas Medical Center quality emergency care to neighborhood communities 24 hours a day every day, including weekends and holidays.

St. Luke's Diagnostic and Treatment Center - Kirby Glen, which opened in early 2003, offers St. Luke's excellence and free parking in a convenient location.  Kirby Glen includes radiology, cancer treatment facilities, lung therapy, sleep apnea diagnostics, and travel medicine.

Also in 2003, St. Luke’s The Woodlands Hospital opened as part of St. Luke's Episcopal Health System.  The Woodlands' facility provides the compassionate care people have come to expect from St. Luke's.  The staff delivers this care in state-of-the-art facilities that include an emergency department, newborn and infant nurseries, diagnostic imaging services, labor and delivery rooms, family lounges on each floor, and more.

In October 2008, St. Luke's Sugar Land Hospital opened as part of St. Luke's Episcopal Health System.  The five-story, 200,000 square foot, 100-bed facility offers inpatient and outpatient services, and features 64 med/surgical beds, 16 private rooms dedicated to women’s services, a 16-bed intensive care unit and comprehensive diagnostic and imaging services.  This facility provides an array of medical and surgical clinical services, including women’s health, emergency care, intensive care and diagnostic and interventional cardiac catheterization labs.

In September 2009, St. Luke’s Lakeside Hospital in The Woodlands, Texas opened its doors.  This facility specializes in sports medicine and orthopedic/spine surgery services.

St. Luke's Hospital at The Vintage is currently under construction.